Born in Chicago, IL; educated at the Chicago Conservatory (piano), Marquette University, Milwaukee, WI (philosophy) and the Lee Strasberg Institute, Los Angeles; daughter of John Madigan, a prominent Chicago attorney and media personality. Former rock musician turned lead and supporting player of stage, film and TV. Married actor Ed Harris in 1983, with whom she's appeared in Robert Benton's PLACES IN THE HEART (1984), Louis Malle's ALAMO BAY (1985), Harris' own POLLOCK (2000), JUST A DREAM (2002), UNFORGIVABLE BLACKNESS: THE RISE AND FALL OF JACK JOHNSON (2004), WINTER PASSING (2005), GONE BABY GONE (2007), and ONCE FALLEN (scheduled for 2009). Other notable screen credits include LOVE CHILD (1982), LOVE LETTERS and STREETS OF FIRE (both 1984), TWICE IN A LIFETIME (1985), ZEISTERS (1986), NOWHERE TO HIDE (1987), THE PRINCE OF PENNSYLVANIA (1988), FIELD OF DREAMS and UNCLE BUCK (both 1989), THE DARK HALF (1993), FEMALE PERVERSIONS (1996), LOVED (1997), WITH FRIENDS LIKE THESE... (1998), A TIME FOR DANCING (2000), THE SLEEPY TIME GAL (2001), THE LARAMIE PROJECT (2002), IN THE LAND OF MILK AND HONEY and THE DISCONTENTS (both 2004), and THE LAST FULL MEASURE (scheduled for 2009). Recent television appearances include a recurring role on "Carnivàle" as Iris Crowe (2003-05) and two episodes of "Criminal Minds" (2007). Madigan and Harris were among a strong minority of attendees of the 2000 Academy Awards to rufuse to applaud during director Elia Kazan's acceptance of his honorary Oscar®. They were protesting Kazan's contribution to the Hollywood blacklistling during the Cold War.  Nominated for Supporting Actress 1985: TWICE IN A LIFETIME 1 nomination